Amy Rosenzweig, PhD

Weinberg Family Distinguished Professor of Life Sciences and Professor of Molecular Biosciences and of Chemistry, Weinberg College of Arts and Sciences

Member, Chemistry of Life Processes Institute

Rosenzweig is a leader in the fields of bioinorganic chemistry and structural biology. Her laboratory focuses on metalloproteins, which comprise up to 50 percent of all proteins. Rosenzweig’s work has provided seminal insights into how metalloenzymes catalyze complex and difficult chemical transformations and how cells acquire and distribute essential yet toxic metal ions.

Rosenzweig and her research group use X-ray crystallographic, spectroscopic, biochemical and genomic approaches to attack problems at the forefront of bioinorganic chemistry. Current areas of interest include biological methane oxidation, metal uptake and transport, and oxygen activation by metalloenzymes.

Her numerous honors include being elected a fellow of the American Academy of Arts and Sciences (2014) and a fellow of the American Association for the Advancement of Science (2007). Rosenzweig was named a MacArthur Fellow in 2003.

Rosenzweig received the Royal Society of Chemistry Joseph Chatt Award (2014), the American Chemical Society Nobel Laureate Signature Award for Graduate Education (2006) and an honorary Doctor of Science degree from Amherst College (2005). She is currently on the editorial boards of the journals Science and Biochemistry.

Publications

Balasubramanian, R.; Smith, S. M.; Rawat, S.; Yatsunyk, L. A.; Stemmler, T. L.; Rosenzweig, A. C. Oxidation of methane by a biological dicopper centre. Nature 2010, 465, 115-119.

Boal, A. K.; Cotruvo, J. A., Jr.; Stubbe, J.; Rosenzweig, A. C. Structural basis for activation of class Ib ribonucleotide reductase. Science 2010, 329, 1526-1530.

Traverso, M. E.; Subramanian, P.; Davydov, R.; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C. Identification of a hemerythrin-like domain in a P1B-type transport ATPase. Biochemistry 2010, 49, 7060-7068.

Balasubramanian, R.; Levinson, B. T.; Rosenzweig, A. C. Secretion of flavins by three species of methanotrophic bacteria. Appl. Environ. Microbiol.2010, 76.

Walker, C. B.; de la Torre, J. R.; Urakawa, H.; Klotz, M. G.; Lawton, T. J.; Pinel, N.; Arp, D. J.; Brochier-Armanet, C.; Chain, P. S. G.; Chan, P. P.; Golabgir, A.; Hemp, J.;Hügler, M.; Karr, E. A.; Könneke, M.; Shin, M.; Lawton, T. J.; Martens-Habbena, W.; Sayavedra-Soto, L. A.; Lang, D.; Sievert, S. M.; Rosenzweig, A. C.; Manning, G.; Stahl, D. A. The Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification andautotrophy in globally distributed marine crenarchaea. Proc. Natl. Acad. Sci. USA 2010, 107, 8818-8823.

Boal, A. K.; Rosenzweig, A. C. Crystal structures of cisplatin bound to a human copper chaperone. J. Am. Chem. Soc. 2009, 131, 14196-14197.

Boal, A. K.; Rosenzweig, A. C. Structural biology of copper trafficking. Chem. Rev. 2009, 109, 4760-4779.

Lawton, T. J.; Sayavedra-Soto, L. A.; Arp, D. J.; Rosenzweig, A. C. Crystal structure of atwo-domain multicopper oxidase: implications for the evolution of multicopper blue proteins. J. Biol. Chem. 2009, 284, 10174-10180.

Hakemian, A. S.; Kondapalli, K. C.; Telser, J.; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C. The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b. Biochemistry2008, 47, 6793-6801.

Lieberman, R. L.; Rosenzweig, A. C. Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane, Nature2005, 434, 177-182.

Select Honors and Awards

Elected Fellow, American Academy of Arts and Sciences 2014
Elected Fellow, American Association for the Advancement of Science, 2007
American Chemical Society Nobel Laureate Signature Award for Graduate Education, 2006
Honorary Degree, Doctor of Science, Amherst College, 2005
MacArthur Fellow, 2003
Camille Dreyfus Teacher Scholar Award, 2001
David and Lucile Packard Fellow, 1999
Her numerous honors include being elected a fellow of the American Academy of Arts and Sciences (2014) and a fellow of the American Association for the Advancement of Science (2007). Rosenzweig was named a MacArthur Fellow in 2003.