CLP Virtual Symposium

February 2, 2021

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CLP Virtual Symposium

Wednesday, May 26, 2021  |   1:00 pm – 5:30 pm

Supported by the Chemistry of Life Processes Predoctoral Training Program NIH/ NIGMS 2T32GM15538-08

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1:00

–

1:10

Welcome and Opening Remarks

Molly Frey, Grad Student Planning Committee

1:10

–

2:10

Session 1 – CLP Trainee Research Presentations
1:10 – 1:25

Systematic Engineering of VLPs to Identify Optimal Characteristics of Nanoparticle Delivery
Bon Ikwuagwu

Bon is a ChBE student whose mentors are Danielle Tullman-Ercek and Tom Meade.
1:25 – 1:40

SAMDI-MS for the Development and Implementation of High-Throughout Biochemical Assays
Elamar Hakim Moully

Elamar is a Chemistry student who will defend her thesis in June. Her mentors are Milan Mrksich and Chad Mirkin. She has accepted a program manager position at the University of Chicago. She will be working for the myCHOICE program, a professional development program for graduate students and postdocs.
1:40 – 1:55

Genetically targeted proteomics in mammalian neural circuits
Vasin Dumrongprechachan

Vas is an IBIS student whose mentors are Yevgenia Kozorovitskiy and Neil Kelleher.
1:55 – 2:10

Association of Apolipoprotein Chemical Variation to Human Cardiometabolic Health Indices
Henrique dos Santos Seckler

Henrique is a Chemistry student who defended his thesis already, and will graduate in June. His mentors are Neil Kelleher and John Wilkins. Henrique is currently working at Alliance Pharma, a contract research organization in Malvern, PA. He works in quantitative and qualitative liquid-chromatography/mass-spectrometry method-development for large molecules.

2:15

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3:15

Session 2 – CLP Alumni Career Panel

Jen Ferrer, PhD, Tempus Labs, Inc.

Jen Ferrer is a graduate of the IBiS (Biology) PhD program at Northwestern where she worked for Dr. Chad Mirkin (Chemistry) and Dr. Jason Wertheim (Biomedical Engineering). As a predoctoral student, she developed a novel liposomal nanoparticle for drug delivery and immune modulation and studied the effects both nanoparticle chemistry and the immune system had on in vivo trafficking.

After graduating, Jen joined Monopar Therapeutics, an oncology-focused company co-founded by a CLP faculty member and board member, to work in business development. Currently, Jen is a Senior Alliance Manager at Tempus Labs, a tech company using clinical and genomic data to drive precision medicine. Jen received a BS in Biology from the University of Illinois, an MS in Biotechnology from Rush University, and holds a certificate in management from the Kellogg School of Management, and an MBA from the Quantic School of Business and Technology.

 

Stefan Kathman, PhD, The Scripps Research Institute

Stefan was born in Cincinnati, OH and got his BA in Chemistry at Harvard University. After working as a medicinal chemist for Cubist Pharmaceuticals for two years, he entered the Chemistry PhD program at Northwestern where he was a CLP trainee.

At Northwestern, he studied the biochemistry and druggability of ubiquitin ligases in Alexander Statsyuk’s lab.  His secondary mentor was Amy Rosenzweig. After graduating, Stefan joined the lab of Benjamin Cravatt at The Scripps Research Institute in La Jolla, CA as a postdoctoral research associate. He currently is using chemical proteomics to discover new drug targets from phenotypic screens of cancer cells.

 

Ryan McClure, PhD, AbbVie, Inc.

Ryan McClure obtained his B.S. in Chemistry from the Illinois Institute of Technology in 2011. He then earned his Ph.D. in Chemistry from Northwestern University in 2016 under the joint mentorship of Prof. Neil Kelleher and Prof. Regan Thomson as an NIH NIGMS T32 Predoctoral Fellow. At Northwestern, he worked on the discovery, synthesis, and bioactivity evaluation of seven natural products including the flavopeptins. He also participated in the development of the metabologenomics platform, the discovery platform for biotech startup, MicroMGX.

In 2017, Dr. McClure joined AbbVie, Inc. as a Senior Scientist in the Proteomics and Chemical Biology groups—applying chemoproteomic techniques to target engagement, mechanisms of action, and off-target identification. Since 2020, he has focused on improving understanding of targeted protein degradation across AbbVie therapeutic area programs.

 

Moderators: Ada Kwong and Kosuke Seki, Grad Student Planning Comm.

3:15

–

4:15

Session 3 – Northwestern Faculty Speaker

Kidney Diseases – A Silent Public Health Crisis

Susan E Quaggin, MD
Director, Feinberg Cardiovascular and Renal Research Institute
Chief, Division of Nephrology and Hypertension, Department of Medicine
Charles H. Mayo, MD, Professor, Professor of Medicine

 

Dr. Susan E. Quaggin, MD, FRCP(C), FASN, is a graduate of the University of Toronto where she completed her residency and served as chief medical resident for the University’s St. Michael’s Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and post-doctoral training.  Dr. Quaggin’s research focuses on fundamental processes needed to establish and maintain the integrity of the specialized vascular beds in the kidney and eye. To understand and identify new therapeutic targets, she’s worked to develop genetic mouse models that allow cell and time-specific manipulation of functional genes. Translation of her group’s findings regarding the vasculature reveals pathogenic mechanisms and new therapeutic targets for a number of diseases, including diabetic kidney and eye disease, nephrotic syndrome, and glaucoma.

Currently she is the Charles Horace Mayo professor of medicine at Northwestern University where she serves as the Chief of the Division of Nephrology & Hypertension and the Director of the Feinberg Cardiovascular and Renal Research Institute.  Dr. Quaggin was elected to the American Society for Clinical Investigation in 2006, the Association of American Physicians in 2013 and the National Academy of Medicine in 2019 and is President-elect of the American Society of Nephrology.

4:15

–

5:15

Session 4 – Keynote Speaker

Understand the anti-cancer STING pathway and harness it to treat metastatic cancers

Lingyin Li, PhD
Assistant Professor of Biochemistry, Stanford University School of Medicine

 

Dr. Lingyin Li is an assistant professor in the Biochemistry Department at Stanford School of Medicine. She is also a fellow at the Stanford ChEM-H institute. She attended the University of Science and Technology of China, where she majored in Polymer Physics in the Chemistry and Chemical Engineering Institute, and earned a bachelor of engineering degree. After obtaining her Ph.D in Chemistry from the University of Wisconsin-Madison, she moved to Harvard Medical School to seek further biochemical training with Dr. Tim Mitchison.

At Harvard, she collaborated with Novartis Institutes for Biomedical Research to perform reverse pharmacology of known immune modulators to elucidate mechanism and identify potential therapeutic targets. Her research put human STING, a central adaptor protein in the innate immune system, on the map of cancer drug discovery, and led her to the field of innate immunology.

Lingyin joined the faculty at Stanford School of Medicine in September 2015. Her lab has focused on chemical biology of the STING pathway, elucidated the biochemical mechanism of STING activation, established the extracellular role of STING’s ligand, cGAMP, as an immunotransmitter, elucidated three molecular mechanisms of how it traffics between cells, and finally hypothesized and provided key evidence that ENPP1, the cGAMP hydrolase, is an innate immune checkpoint and developed best in class ENPP1 inhibitors for cancer immunotherapy. These discoveries earned her the NIH New Innovator Award in 2017 and she was named one of the C&En News Talented 12 in 2020.

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chemistry of life processes institute 

Richard and Barbara Silverman Hall for Molecular Therapeutics and Diagnostics

2170 Campus Drive

Evanston, IL 60208

(847) 467-2303

clp-info@northwestern.edu