MAKING SENSE OF PROTEINS

Learn more about how proteins underly disease and how researchers in the Institute’s Proteomics Center of Excellence are using top-down proteomics to advance medicine.

chemistry of life processes institute

Home to the researchers who discovered the blockbuster drug Lyrica®, CLP is a world leader in protein science and drug discovery. CLP is using its unique capabilities for protein-informed drug discovery and diagnostic development to advance the detection and treatment of ALS, Alzheimer’s, cancer, kidney disease, transplant rejection, and other health conditions.

CLP’S NIH GRADUATE TRAINING PROGRAM

CLP’s NIH Graduate Training Program trains chemistry, biology and engineering graduate students to work across disciplinary boundaries to address the big problems in biomedical research.

CLP’S NIH GRADUATE TRAINING PROGRAM

In this episode, Nautilus Biotechnology’s Parag Mallick sits down with Northwestern University Professor and proteoform pioneer, Neil Kelleher to dive deep into the biology of proteoforms.

NORTHWESTERN FEINBERG SCHOOL OF MEDICINE ‘BREAKTHROUGHS’ PODCAST | THE HUMAN GENOME PROJECT FOR PROTEINS

Millions of molecular proteins are swimming through our body’s cells and many studies have discovered that these proteins are the main drivers of all human diseases. Scientists are now mapping proteins the way the Human Genome Project mapped genes. Neil Kelleher, PhD, director of Northwestern Proteomics, is at the forefront of the Human Proteoform Project and explains how it could lead to more targeted and effective diagnostics and treatments for diseases.

CLP LCC CONVERGENCE WORKSHOP | CANCER GENOMICS AND REDOX EPIGENETICS JUNE 29 2023

The CLP-Lurie Cancer Center Convergence Workshop brought together Chemistry of Life Processes Institute and Lurie Cancer researchers to discuss some of Northwestern’s most innovative cancer epigenetics research and methods and opportunities for collaboration. The online program covered cutting-edge physical sciences approaches and technologies developed by CLP faculty and clinically relevant cancer models, mechanisms, and targets identified by Lurie Cancer Center researchers.

CLP FEINBERG CONVERGENCE WORKSHOP | SEPT. 14, 2022

The CLP-Feinberg School of Medicine Convergence Workshop, held on September 14, 2022, was the first of a new team science workshop designed to foster innovative research collaborations at Northwestern University that address unmet clinical needs. The Workshop featured lightening talks by CLP faculty researchers and Feinberg physician-scientists, resulting in a vigorous exchange of ideas and several new research collaborations.

CLP FACULTY CHALK TALK | ‘HOW BACTERIA EAT METHANE’ WITH AMY ROSENZWEIG, PHD, | 5/10/23

CLP member Amy Rosenzweig, PhD, explains her lab’s efforts to understand how biocatalysts produced by methane-consuming bacteria work.

CLP FACULTY CHALK TALK | XIAOYU ZHANG, PHD, 1/18/2023

With researchers touting recent success in sequencing the human genome’s remaining gaps, an emerging frontier is proteomics: identifying and studying an entire set of expressed proteins in the human body and other organisms. This video explains the basics of the field.

CLP FACULTY CHALK TALK 9/9/22 | NORTHWESTERN’S GABRIEL ROCKLIN, PHD

CLP member Gabriel Rocklin, PhD, discusses his lab’s ‘High-throughput Approaches to Protein Stability, Dynamics, and Design” and how large experimental datasets and new machine learning methods are currently transforming numerous areas of biology.

PROTEOMICS 101

With researchers touting recent success in sequencing the human genome’s remaining gaps, an emerging frontier is proteomics: identifying and studying an entire set of expressed proteins in the human body and other organisms. This video explains the basics of the field.

CLP FACULTY CHALK TALK | SHANA KELLEY, PHD, 3/17/2024

CLP member Xiaoyu Zhang, PhD, explains “Expanding the Landscape of E3 Ligases for Targeted Protein Degradation.”

User Spotlight Seminar | Repurposing Chemotherapies Against Meningiomas

Northwestern pathologist Craig Horbinski discusses how he screened a large panel of FDA-approved chemotherapies using patient-derived meningioma cells to identify candidates for repurposing against meningioma, i.e., tumors that arises from the membranes surrounding the brain and spinal cord.

CLP Faculty Chalk Talk │ Erik Andersen, phd

Erik Andersen, PhD, Associate Professor of Molecular Biosciences, Northwestern University, and Chemistry of Life Processes Member, discusses ‘Individualized Genetics & Genomics of Drug Responses’.

CLP FACULTY CHALK TALK │ MICHAEL JEWETT, PHD

Michael Jewett, PhD, Charles Deering McCormick Professor of Teaching Excellence; Walter P. Murphy Professor of Chemical and Biological Engineering and Chemistry of Life Processes Institute Member discusses ‘Bioengineering Beyond Cells to Eneable a Fair and Sustainable 21s Century’.  

CLP FACULTY CHALK TALK │ JULIA KALOW, PHD

Michael Jewett, PhD, Charles Deering McCormick Professor of Teaching Excellence; Walter P. Murphy Professor of Chemical and Biological Engineering and Chemistry of Life Processes Institute Member discusses ‘Bioengineering Beyond Cells to Eneable a Fair and Sustainable 21s Century’.  

CLP FACULTY CHALK TALK │ MICHAEL JEWETT, PHD

Michael Jewett, PhD, Charles Deering McCormick Professor of Teaching Excellence; Walter P. Murphy Professor of Chemical and Biological Engineering and Chemistry of Life Processes Institute Member discusses ‘Bioengineering Beyond Cells to Eneable a Fair and Sustainable 21s Century’.  

CLP FACULTY CHALK TALK │ MICHAEL JEWETT, PHD

Michael Jewett, PhD, Charles Deering McCormick Professor of Teaching Excellence; Walter P. Murphy Professor of Chemical and Biological Engineering and Chemistry of Life Processes Institute Member discusses ‘Bioengineering Beyond Cells to Eneable a Fair and Sustainable 21s Century’.  

CLP Faculty Chalk Talk │ Erik Andersen, phd

Erik Andersen, PhD, Associate Professor of Molecular Biosciences, Northwestern University, and Chemistry of Life Processes Member, discusses ‘Individualized Genetics & Genomics of Drug Responses’.

CLP FACULTY CHALK TALK │ MICHAEL JEWETT, PHD

Michael Jewett, PhD, Charles Deering McCormick Professor of Teaching Excellence; Walter P. Murphy Professor of Chemical and Biological Engineering and Chemistry of Life Processes Institute Member discusses ‘Bioengineering Beyond Cells to Eneable a Fair and Sustainable 21s Century’.  

CLP FACULTY CHALK TALK │ JULIA KALOW, PHD

‘Mimicking Life with Light: Dynamic Light-Controlled Biomaterials’, a Chemistry of Life Processes Institute Faculty Chalk Talk on May 12, 2021 with Julia Kalow, PhD, Assistant Professor of Chemistry, Northwestern University.

Northwestern | Proteomics – Decoding protein (short)

CLP’s Proteomics Center of Excellence is a major hub advancing proteoform measurement and biology using top-down proteomics.

Novel Compound Improves the Health of Diseased Upper Motor Neurons | Ozdinler & Silverman – 2021

Improving mitochondria and ER stability helps eliminate UMN degeneration. Study collaborators, Pembe Hande Ozdinler and Richard B. Silverman, are members of the Chemistry of Life Processes Institute at Northwestern University..

The Cell- Based Human Proteome Project | Neil Kelleher | TEDxNorthwesternU

Neil’s TEDx Talk, A Plan to Weigh Every Protein in the Human Body: The Cell- Based Human Proteome Project presents a “big science” project with huge implications for how proteins in the human body are catalogued and used for drug therapies and treatments.