WHEN:
Tuesday, June 29, 2021, 11 AM – 12 PM (ONLINE)
WHAT:
Neil L. Kelleher, PhD, Walter and Mary Glass Professor of Molecular Biosciences, Professor of Chemistry; Faculty Director of Northwestern Proteomics; and Interim Director of Chemistry of Life Processes Institute at Northwestern University, will deliver the NUCATS Institute’s upcoming Translational Applications in Medical Research lecture. The event is a biannual collaboration between the NUCATS Institute and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
DESCRIPTION:
Case Studies of Proteoforms in Human Health and Disease
In humans, proteins that arise from single genes have diverse sources of possible variation, including alternative RNA splicing and post-translational modification, which create many different molecular forms. “Proteoform” is the term used for distinct protein molecules that incorporate such variations (including genetic mutation). There are many examples of proteoforms that are measured in clinical practice. For example, hemoglobin A1C is a proteoform of hemoglobin modified via glycation. Northwestern Proteomics is systematically mapping the proteoforms of key proteins in four main disease areas. Through a Northwestern Proteomics Initiative (NPI), we seek expanded engagement for translational research leveraging a leading position in the science and technology of proteoform measurement from clinical specimens. Examples in cardiology (ApoA-I) and immunology (IgG repertoire recognizing SARS-CoV-2) will be described, along with future collaborative opportunities via the NPI.
Virtual Event. Registrants will be sent the connection link before the event.
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